Benefits of L-Lysine




benefits of l-lysine

In this article, we discuss the 10 amazing health benefits of L-lysine injections, as well as indications, contraindications, and food sources. L-lysine is an essential amino acid that serves as a building block for proteins in the body.¹ Lysine was first isolated from casein (a milk phosphoprotein) in 1889. It was first introduced in the United States as lysine hydrochloride in 1955.

Since it is necessary for human function, lysine must be introduced into the body through food or supplements because it cannot be synthesized in the body. Lysine supplements are touted as a natural remedy for a number of health problems. There are many conditions that could be improved by numerous L-lysine health benefits.

1. Benefits of L-Lysine: Prevention and treatment for cold soresbenefits of l-lysine

Cold sores are fluid-filled blisters that often appear on the lip and the corners of your mouth. They are symptoms of an infection that is caused by the herpes simplex virus type 1 (HSV-1). 

Lysine injections are commonly prescribed to help prevent the replication of this virus by blocking the absorption of arginine, an amino acid necessary for the viruses to reproduce, and for viral infections to progress. ²

2. Reduces the risk of heart disease with L-Lysine

Heart disease is the leading cause of death for people of most ethnicities in the United States, including African Americans, Hispanics, and Caucasians. Most doctors say it’s due to the hardening of arteries and coronary arteries closest to the heart are under the greatest pressure causing collagen to fracture, resulting in the formation of a blood clot and death. Lysine supplements are crucial for optimum long-term health of the coronary arteries by forming part of the collagen molecules vital in strengthening the artery walls. Plus, l-lysine is required in the production of carnitine that plays an important role in reducing the level of cholesterol in the body.

3. Aids in the growth and maintenance of bonesLysine Injections

One of L-lysine’s health benefits is maintaining bone mass. Studies have shown that  L-lysine plays a role in increasing calcium absorption via digestion and decreases the amount of calcium that is lost in the urine in order to use in new bone formation, hasten fracture healing time, or reversing and preventing osteoporosis or weak bones by reducing bone loss.

L-lysine supplements are also vital for the production of collagen and muscle growth which contributes to the stimulation of new bone formation. Bone matrix is comprised of about 40% organic compounds, 90% of which is collagen that makes bone tough and flexible.  ³

4. Boosts athletic performance

L-lysine supplements help build lean body mass and promote muscle strength because it is a building block for protein and is used to create carnitine, a nutrient responsible for converting fatty acids into energy and helping to lower cholesterol. Some studies suggest that one of the L-lysine benefits is to help muscle tissue recover after stress. Athletes sometimes use lysine supplements as a source of protein.

5. Reduces anxietybenefits of l-lysine

L-lysine supplementation has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. When combined with arginine, hormonal stress responses in humans with high trait anxiety is normalized because they partially bind to serotonin receptors and reduce levels of the stress hormone cortisol.

6. Promotes wound healing

Wound healing is a combination of cellular and molecular processes requiring different minerals, vitamins, and other factors aimed at restoring the original design of damaged tissue. L-lysine supplements appear to have a crucial role in speeding up the repair process because this amino acid acts as a binding agent, thereby increasing the number of new cells at a wound. It may even promote the formation of new blood vessels. L-lysine supplements are essential for the formation of collagen, an essential protein that affects wound repair. Without adequate lysine, wound healing is impaired too.

Lysine Supplements7. Useful for skin, nails, and hair health

Getting an adequate amount of l-lysine may contribute to overall skin health. Together with vitamin C, L-lysine injections create ample amounts of procollagen that then gets converted to the different types of collagen to help enhance your skin and appearance and protect your skin from damage and aging. 

L-lysine is also present in the hair’s root, and it is responsible for the shape and volume of the hair and promotes regular hair growth.  Its deficiency can result in hair loss.

8. Liver and Immune System Support

L-lysine enters the liver and acts as a defense to all of the viruses that are responsible for liver disease and autoimmune disorders. Viruses hate lysine because it deters them from proliferating. The L-lysine health benefit is to strengthen the immune system in the liver and aid in some of the organ’s most important functions.

L-lysine supplements containing the biologically active L-isomer of the essential amino acid lysine promotes healthy tissue function, growth, healing, and improves the immune system. One of the many L-lysine benefits, when combined with vitamin C, is that it inhibits the invasion of healthy tissue by cancerous cells. One animal study shows that lysine, in combination with antioxidant catechin, reduced cancer cell growth in mice.

9. Relieves migraine and other types of pain and inflammationbenefits of l-lysine

Migraines are thought to be caused by the dilation, or expansion, of cranial blood vessels. Lysine supplements have been used for its analgesic properties in the treatment of migraine headaches and other pain disorders. Additionally, case reports suggest that L-lysine may ameliorate angina pectoris.

10. Regulates blood sugar levels

Another amazing Lysine health benefit is the stimulation of insulin secretion both in healthy individuals and in subjects with type 2 diabetes. Lysine supplements result in a small decrease in serum glucose and an increase in glucagon and insulin concentrations. The results of a small study on 12 healthy volunteers suggest that lysine injections can slow the rise in blood glucose levels after eating. 


When people do not get enough lysine in the diet, degradation of the internal cells can happen and may result in a range of health conditions such as the following:

  • Hair loss
  • Irritability
  • Nausea
  • Poor concentration
  • Fatigue
  • Slow  growth and development
  • Bloodshot eyes
  • Kidney stone formation
  • Chronic viral infections

Good Sources of L-lysine

Here are a few of the best food sources to ensure you’re meeting your essential needs of this amino acid.

  • Lean beef and lamb 
  • Parmesan cheese, whole-milk ricotta cheese, non-fat cottage cheese
  • Turkey and chicken 
  • Pork 
  • Roasted soybeans 
  • Tuna 
  • Shrimp 
  • Pumpkin seeds
  • Eggs 
  • Beans and peas
  • Skim-milk yogurt

Benefits of L-lysine Injections for Weight Loss 

Lysine is not only beneficial in boosting immunity but is also a fat burner. Using both hCG injections and l-lysine injections in conjunction therapeutically can help fight fatigue, increase energy, and weight loss since L-lysine helps in the creation of carnitine, which converts fatty acids into usable energy by moving them out of cell’s cytoplasm and into their mitochondria. Once they are in the mitochondria, the fatty acids are used as energy rather than stored on the body.  As it increases the energy levels, it also boosts the endurance thus supporting the exercise performance and overall physical performance.

While on the hCG diet, many dieters may experience fatigue due to the low-calorie diet, but the use of L-lysine injection supplements will provide the stamina needed and boost your energy while you are on your low-calorie diet. L-lysine is an essential amino acid that helps build lean body mass and promotes muscle strength because it improves protein synthesis. To get more information about hCG-Lysine injection therapy near you, contact The HCG Institute to ensure the information displayed on this page applies to your personal circumstances.

Supplementing with L-lysine

Lysine supplements are available in tablets, capsules, creams, liquids, and injectables, and is usually sold in the L-lysine form. For supplementing through diet, L-lysine is commonly found in meat, fish, eggs, dairy products, avocados, and nuts.  Introducing one of these foods into your daily diet is one way to make sure you’re getting it. However, the bioavailability of lysine is reduced with conventional food preparation methods, such as heating foods in the presence of fructose or glucose, sucrose or yeast, and cooking in the absence of moisture at high temperatures. This can cause the L-lysine health benefits to decrease. Therefore, L-lysine injection supplements can be extremely beneficial in cases where you know you aren’t able to meet your daily value recommendations of specific nutrients. 

Experts continue to research effective dosages for clinical purposes, while some studies have shown benefits for doses of 100mg to 4g per day.  If you’re dealing with a chronic symptom or illness, taking only 500mg of L-lysine a day might not be sufficient. If you’re fighting off viruses, including those that cause cold sores a higher dosage of L-lysine supplement may be necessary. But if you only want to help shield yourself from picking up one of the hundreds of possible microorganisms, taking a smaller dose of lysine supplements can be a protective step. Nevertheless, it is important to discuss with a physician the exact dosage you plan on taking to best support your specific health needs. If you are looking for L-lysine injections near you, The HCG Institute is the perfect telemedicine choice. We can help you reap the health benefits of L-lysine supplementation!

Who Can Benefit from L-Lysine Supplementation?

The essential amino acid l-lysine plays an important role in the well being of the body and everyone needs this.  Although deficiency of this amino acid is quite rare, there are instances where l-lysine supplementation is necessary, for some people more than others:

1. Older women 

As women age, they naturally lose muscle mass and strength. According to the Journal of Nutrition, daily lysine supplementation, along with arginine and beta-hydroxy-beta-methylbutyrate (better known as HMB) positively increases muscle functionality, strength, mass, as well as protein synthesis in older women.

2. Athletes 

According to the University of Maryland Medical Center, L-lysine benefits your muscles because it helps them recover faster from the stress of a hard workout, game, or race. 

3. Vegans and Vegetarians

Because L-lysine is commonly found in diets rich in animal products, vegans and vegetarians are most susceptible to a deficiency of this amino acid. 

4. Patients with marasmus and kwashiorkor

With these conditions, the body breaks down the muscles to use as energy, thus, L-lysine injections prevent further muscle wasting for patients suffering from these diseases.

5. People with osteoporosis 

L-lysine aids in calcium absorption and reduces the amount of calcium that is lost in the urine, thereby preventing bone loss. 

6. Burn patients

L-lysine is necessary for the formation of collagen and thus can help hasten the wound healing process. 

Side Effects of L-lysine

While eating food sources that contain lysine is considered safe, the use of L-lysine supplements has been known to cause some minor digestive reactions such as:

  •  stomach pain
  •  nausea 
  • diarrhea 

Special Considerations

Lysine supplements are generally safe but require certain precautions.

  • Lysine should also be used with caution during pregnancy and lactation due to a lack of research on the effects. 
  • While L-lysine benefits those with a large number of diseases, there is evidence that it can also pose a risk to patients with kidney impairment because it can cause chronic kidney (renal) failure, inflammation in the kidney (interstitial nephritis) and increased calcium absorption.
  • HIV-positive patients with liver impairment should also be cautious in taking L-lysine supplement because it can increase the viral load of HIV patients.
  • Use of calcium supplements with l-lysine supplements may enhance aminoglycoside toxicity associated with increased absorption and reduced elimination of calcium. 
  • Lysine may also interact with a group of antibiotics called aminoglycosides, potentially resulting in kidney damage. 



  1. Compound summary for CID 122198194: (2S)-6-amino-2-azaniumylhexanoate. (n.d.). Retrieved from
  2. Kagan C. Letter: Lysine therapy for herpes simplex. Lancet. 1974 Jan 26;1(7848):137. doi: 10.1016/s0140-6736(74)92374-5. PubMed PMID: 4130340.
  3. Fini M, Torricelli P, Giavaresi G, Carpi A, Nicolini A, Giardino R. Effect of L-lysine and L-arginine osteoblast cultures from normal and osteopenic rats. Biomed Pharmacother. 2001;55(4):213-220.
  4. Morales A, García H, Arce N, Cota M, Zijlstra RT, Araiza BA, Cervantes M. Effect of L-lysine on expression of selected genes, serum concentration of amino acids, muscle growth and performance of growing pigs. J Anim Physiol Anim Nutr (Berl). 2015 Aug;99(4):701-9. doi: 10.1111/jpn.12267. Epub 2014 Oct 29. PubMed PMID: 25354230.
  5. Srinongkote, S., Smriga, M., Nakagawa, K. & Toride, Y. (2003) Nutr. Neurosci. 6, 283-289. [PubMed] [Google Scholar]
  6. Spallotta F, Cencioni C, Straino S, et al. Enhancement of lysine acetylation accelerates wound repair. Commun Integr Biol. 2013;6(5):e25466. doi:10.4161/cib.25466
  7. Tfelf-Hansen P. The effectiveness of combined oral lysine acetylsalicylate and metoclopramide in the treatment of migraine attacks. Comparison with placebo and oral sumatriptan. Funct Neurol. 2000;15(Suppl 3):196-201.
  8. Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016 Oct;17(10):970-6. doi: 10.1111/obr.12436. Epub 2016 Jun 22. Review. PubMed PMID: 27335245.
  9. Racusen, L C et al. “Effects of lysine and other amino acids on kidney structure and function in the rat.” The American journal of pathology vol. 120,3 (1985): 436-42.