Are Hydroxocobalamin B12 Injections Right for You?

In the realm of vitamins, vitamin B12 has been regarded as one of the most indispensable for the human body. It keeps the blood and brain cells healthy and makes the protective coating surrounding the body’s nerves. Without a doubt, vitamin B12 plays a critical role in many of the body’s most important functions.

In the United States, deficiency in vitamin B12 may be more widespread than previously thought! Researchers found out that more than 40 percent of the population is deficient in vitamin B12. There are many driving factors in B12 deficiency including diet, vitamin B12 malabsorption from food, pernicious anemia, postsurgical malabsorption, and in many cases, the cause is unknown. Needless to say, you should not ignore B12 vitamins whether you’re vegan, vegetarian, a meat-eater, young or old. 1

Cyanocobalamin vs. Methylcobalamin vs. Hydroxocobalamin

Many people turn to vitamin B12 supplements to help meet their needs and prevent a deficiency but with the many forms of vitamin B12 commercially available in the market it is easy to get confused about which type you should supplement with. This article examines each type of vitamin B12 and how to choose the right B12 for anyone looking for supplementation:

b12 injectionsCyanocobalamin B12:  a synthetic and an inactive form of supplemental vitamin B12 frequently used in supplements. This form must first be broken down to cobalamin and cyanide to be converted into the two bioactive coenzymes before being utilized by the body.2  It takes more than 48 hours for cyanocobalamin B12 to eventually convert to usable methylcobalamin. The process used to detoxify cyanocobalamin could deplete glutathione reserves and even then only a small amount is converted. Cyanocobalamin could cause cyanide toxicity particularly in those with kidney failure.3

Methylcobalamin B12: a naturally occurring form of vitamin B12 that can be obtained through supplements as well as food sources. It is the most bioavailable form of Vitamin B12, i.e. it is the most readily absorbed. Methylcobalamin is used primarily in your liver, brain, and nervous system. In fact, methylcobalamin is the specific form of B12 needed for nervous system health. 

However, research shows that methylcobalamin is not very sustainable and doesn’t increase levels of adenosylcobalamin necessary for the metabolism of fats and amino acids, as well as the formation of the protective myelin sheath around your nerve cells.4 

Hydroxocobalamin B12: a natural form of B12 produced by certain microorganisms and occurs in the body and it makes up almost half of all the vitamin B12 found in our blood. Of all the vitamin B12 forms, hydroxocobalamin is one of the most common forms of the vitamin in natural foods and is the first-line therapy for those with long-term B12 deficiency.5

To conclude, Methylcobalamin or Hydroxocobalamin is recommended for anyone looking to supplement or treat vitamin B12 deficiencies.

Why is Hydroxocobalamin Unique?hydroxocobalamin b12

  • Hydroxocobalamin can increase the levels of methylcobalamin and adenosylcobalamin because it can be converted to these both active forms; whereas, methylcobalamin does not increase adenosylcobalamin levels.
  • Hydroxocobalamin injection does not need glutathione to detoxify it because it can easily be converted to both active forms of B12 and does not contain a toxic donor, cyanide. 
  • Hydroxocobalamin injections can supply your body for longer than the other B12 forms ensuring both an even supply of B12 to the cells and that the body’s stores are optimally replenished, especially during periods of increased body demand.
  •  Hydroxocobalamin likely has the highest affinity to plasma protein and has the longest half-life corresponding to a retention rate of about 75 percent compared with about 20 percent cyanocobalamin.6

Want to know more?

  • Hydroxocobalamin B12 injections have a special function even before being converted into the coenzyme forms. If you’re constantly exposed to carbon monoxide, cyanide, chemical toxins, or consuming cyanide-containing foods then your health may improve enormously with correct vitamin B12 treatment, in the form of hydroxocobalamin injections.

Hydroxocobalamin is an excellent antidote for cyanide, a fast-acting poison that can be lethal. The action of hydroxocobalamin injections in the treatment of cyanide poisoning is based on its ability to bind cyanide ions to form nontoxic cyanocobalamin, which is then excreted in the urine. As a result, this active ingredient is also an excellent option for people who are in the process of quitting smoking and detoxifying from the smoke.7

  • Hydroxocobalamin has a homocysteine-reversing property by converting homocysteine to beneficial methionine that helps with energy production and is essential for the nervous system and normal brain function7 8 

Vitamin B12 deficiency can increase the homocysteine levels resulting in impaired cognitive function, stroke, Alzheimer’s disease, cardiovascular disorders, and osteoporosis. Taking hydroxocobalamin injections can reverse these side effects.

  • Hydroxocobalamin injection is also a scavenger of nitric oxide (NO) radicals that can result in what is known as nitrosative stress. It is believed that nitrosative stress can be the cause of a whole range of illnesses. Vitamin B12, particularly in the form of hydroxocobalamin, is the natural opponent of nitric oxide and renders it harmless in the body.

hydroxocobalamin b12 injectionsHydroxocobalamin Injections vs. Oral B12 Supplements

The absorption of oral vitamin B12 depends on the intrinsic factors produced in your stomach. The intrinsic factor binds to vitamin B12 so that you can absorb it into the blood. People who don’t produce enough intrinsic factor can become deficient. If you are deficient in vitamin B12, then the hydroxocobalamin B12 shots are very effective at raising your blood levels or preventing a deficiency. 

Buy Hydroxocobalamin B12 Injections Near You! 

The hydroxocobalamin injections are prescribed by a doctor and cannot be purchased over the counter. If you are looking to supplement your body with the natural forms of B12, you can buy Hydroxocobalamin Shots online easily at The HCG Institute. We are a telemedicine practice that service patients nationwide so you can now interface with healthcare providers from the comfort of their own home. Simply fill out the Vitamin Intake Form under Step 2 on our Start Now page to get started!



2. Hodgkin DC, Kamper J, Mackay M, Pickworth J, et al. Structure of vitamin B12. Nature. 1956;178:64–66.

3. Spence JD. B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes. Clin Chem Lab Med. 2013 Mar 1;51(3):633-7. doi: 10.1515/cclm-2012-0465. PubMed PMID: 23449527.




7. Thompson JP, Marrs TC. Hydroxocobalamin in cyanide poisoning. Clin Toxicol (Phila). 2012 Dec;50(10):875-85. doi: 10.3109/15563650.2012.742197. Epub 2012 Nov 19. Review. PubMed PMID: 23163594.

8. Maron BA, Loscalzo J. The treatment of hyperhomocysteinemia. Annu Rev Med. 2009;60:39–54. doi:10.1146/