Hydroxocobalamin B12 Injections

Hydroxocobalamin Hydroxocobalamin is a naturally occurring vitamin B12 form mostly found in natural food sources. It is produced by microorganisms and is also found in the body. However, hydroxocobalamin is not a bioactive coenzyme form of vitamin b12, thus needed to be converted within the body into methylcobalamin to be utilized by our body cells. Since it is so common in foods, our body can absorb this form of vitamin B12 particularly well.1 

Hydroxocobalamin bonds to the body’s transport molecules and circulates much longer in the blood than all other forms of vitamin B12, ensuring a long-lasting and balanced vitamin B12 supply. 

Hydroxocobalamin also features an excellent sustained release, which on the one hand ensures an even supply of vitamin B12 for the cells and on the other side also ensures that the body’s B12 store is optimally topped up. In doing this, the body is protected in times of heightened need, such as during periods of stress or difficulty.2 

Hydroxocobalamin vs. Cyanocobalamin

Knowing the best choice of vitamin B12 helps you receive the best results your body needs. It is good to know how to choose the best cobalamin by learning about the key differences between various types of cobalamin:

  • Hydroxocobalamin is a natural form while cyanocobalamin is a synthetic or man-made form of Vitamin B12.
  • Hydroxocobalamin has a much higher rate of absorption than cyanocobalamin.
  • Hydroxocobalamin circulates for much longer in the blood while cyanocobalamin is quickly excreted.
  • Hydroxocobalamin is a natural form and commonly found in foods, our body can absorb this form of vitamin B12 particularly well; whereas cyanocobalamin has to be converted to its active form before they are getting utilized by the body.
  • Hydroxocobalamin has a substantially extended half-life than cyanocobalamin whose half-life is only about six hours.

How Hydroxocobalamin B12 Shots Work

  • It is used as an attractive antidote to cyanide poisoning. Hydroxocobalamin works by helping cells within the body convert cyanide to much less toxic cyanocobalamin which can be excreted from the body through urination.3
  • Needed to form red blood cells that carry oxygen throughout the body, the myelin sheath that surrounds nerve cells, and various proteins.
  • It also plays a role in the metabolism of fat and carbohydrate.
  • Hydroxocobalamin injections can also treat pernicious anemia.
  • It can aid in the treatment of optic nerve degeneration which can result in loss of central vision and also treats poor vision.
  • It works with folate to build the body’s genetic material which is the DNA.
  • It has the longest lasting effect that is useful for detox, fight fatigue, and quitting smoking.4
  • Shown to help improve cognitive functioning.
  • Hydroxocobalamin reduces nitrosative stress by bonding to nitrous oxide which is presumed to be the cause of many autoimmune diseases.5

Hydroxocobalamin B12 and Weight Loss

Currently, vitamin B12 has been linked to weight loss and energy boosts because it helps the body convert fats and proteins into energy that aids in the breakdown of carbohydrates.6 It is well documented that there’s no risk of Vitamin B12 overdose. The body will only use as much as it needs and excretes the excess through urine. Hydroxocobalamin B12 injections can also be given as part of the hCG diet program for weight loss.

Hydroxocobalamin B12 injections vs. Oral B12

Traditionally, vitamin B12 replacement has been administered orally. However, the absorption rate through the gastrointestinal tract is deficient so the physicians at The HCG Institute always recommend giving it via injections. 

Remember that vitamin B12 must attach to a protein called intrinsic factor, which is secreted in the stomach to be absorbed. However, several things can inhibit the secretion of intrinsic factor, which in turn decreases the absorption of B12 around half per dose, regardless of how high the overall dosage level given.7 

On the other hand, vitamin B12 given via injection will give you the maximum benefit because it bypasses the digestive system and goes directly to your bloodstream. Parenteral (non-oral) administration is faster and more efficient than oral supplements and recommended for initial or continued treatment of B12 deficiency. The HCG Institute always recommends the injections over any other route of administering vitamin B12.

Buy Hydroxocobalamin B12 Injections Online

While a balanced diet can ensure a good intake of vitamin B12, it is often still necessary to supplement your body with Hydroxocobalamin B12. Hydroxocobalamin B12 Injections

When buying supplements, it is advisable to avoid products with the active ingredient cyanocobalamin despite its admittedly cheaper price. Try to ensure that the active ingredient listed is Hydroxocobalamin because it offers many clear advantages and is better suited to covering the natural profile of food sources too. Hydroxocobalamin is similarly highly recommended as a supplement, where it can be interchanged or combined with methylcobalamin and adenosylcobalamin.

Our pricing program includes:

  • 10ml vial or 30ml that lasts up to 70 days or 90days respectively. 
  • Injection supplies
  • Prescription
  • Instructions
  • Support is available via phone, email or chat. 

Safeguard your health with Hydroxocobalamin B12 injections from The HCG Institute by starting the ordering process. Complete the Vitamin Intake Form on our Start Now page, and we will contact you to place your order. Alternatively, you can also call us at 877.228.2158, complete our Contact Us form, or email us at [email protected] for recommendations on which program is best suited for your health needs.


1. Farquharson J, Adams JF. The forms of vitamin B12 in foods. Br J Nutr. 1976 Jul;36(1):127-36. PubMed PMID: 820366.

2. Hall CA, Begley JA, Green-Colligan PD. The availability of therapeutic hydroxocobalamin to cells. Blood. 1984 Feb;63(2):335-41. PubMed PMID: 6692038.

3. Thompson JP, Marrs TC. Hydroxocobalamin in cyanide poisoning. Clin Toxicol (Phila). 2012 Dec;50(10):875-85. doi: 10.3109/15563650.2012.742197. Epub 2012 Nov 19. Review. PubMed PMID: 23163594.

4. Wadia NH, Desai MM, Quadros EV, Dastur DK. Role of vegetarianism, smoking, and hydroxocobalamin in optic neuritis. Br Med J. 1972;3(5821):264–267. doi:10.1136/bmj.3.5821.264

5. Pall ML. “Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.” Med Hypotheses. 2001 Aug;57(2):139-45. doi: 10.1054/mehy.2001.1325

6. CHOW BF, STONE HH. The relationship of vitamin B12 to carbohydrate metabolism and diabetes mellitus. Am J Clin Nutr. 1957 Jul-Aug;5(4):431-9. doi: 10.1093/ajcn/5.4.431. PubMed PMID: 13444207.

6. Layden AJ, Täse K, Finkelstein JL. Neglected tropical diseases and vitamin B12: a review of the current evidence. Trans. R. Soc. Trop. Med. Hyg. 2018 Oct 01;112(10):423-435. [PMC free article] [PubMed] [Reference list]