Vitamin B12 Injections: Everything You Need to Know About Them

vitamin b12 methylcobalaminIf you want to know more about vitamin B12 Methylcobalamin to see if supplementation is right for you, then this blog post is what you are looking for! In this article, we’ve got everything you need to know about Vitamin B12 injections. Vitamin B12, medically known as cobalamin, is one of the components of the vitamin B complex that plays an important role in cellular metabolism, as it acts as a cofactor in many biological pathways. Cobalamin is certainly a powerhouse, as it helps make DNA, nerve and blood cells, and is crucial for a healthy brain and immune system. It also plays an important role in weight loss, and overall nutrition and wellness. Your metabolism wouldn’t run smoothly without it.
¹ Vitamin B12 is commonly available in two forms: Cyanocobalamin and Methylcobalamin 


Methylcobalamin Vs. Cyanocobalamin

Vitamin B12 Methylcobalamin

Methylcobalamin is the purer, naturally occurring form of vitamin B12 that can be absorbed and used by the body immediately because it has a methyl donor attached to the cobalamin compound. Methylcobalamin is used primarily in your liver, brain, and nervous system. Most importantly, vitamin B12 methylcobalamin is the specific form of B12 needed for nervous system health. Furthermore, vitamin B12 methylcobalamin makes the folic acid resorbable. Without this step, the body would not be able to metabolize folic acid. ²

Vitamin B12 Cyanocobalamin  

It is a common but synthetic form of vitamin B12 that is often added to foods, however, the body must use precious energy to convert this form into methylcobalamin. Because it is cheaper to produce, it can be made in a laboratory and added to most vitamins and dietary supplements.³

Cyanocobalamin has a cyanide donor, a substance that is not intended to be used in the body. As a result, before the vitamin B12 can be used by the body, it must be broken down and converted by removing the cyanide donor and attaching a methyl donor.


Sources of Vitamin B12buy vitamin b12 injections

Vitamin B12 is a water-soluble vitamin that is naturally found in shellfish, fish and other animal products including liver, meat, poultry, eggs, milk, and other dairy products. Alternatively, it is also available as a dietary supplement and as a prescription medication.


Causes of Vitamin B12 Deficiency

1. Veganism or Vegetarianism

Vitamin B12 deficiency is common among vegans because typical vitamin B12 sources (meat, yogurt, etc.) are simply not present in their diets. Do note that since the liver stores this vitamin, your vitamin B12 stores can last for 3 to 5 years if you go vegan or stop eating foods rich in vitamin B12. The symptoms of B12 deficiency will start showing up after that period.

2. Heavy Drinking

More than moderate levels of alcohol consumption can significantly reduce vitamin B12 absorption and may deplete bodily stores.  Alcohol irritates the mucosal lining of the stomach and intestines. Less hydrochloric acid is produced and less intrinsic factor is secreted when the stomach lining is irritated. Both of these factors contribute to reduced B12 absorption from food.  Decreased hydrochloric acid production can stimulate the growth of intestinal bacteria that use vitamin B12, which further reduces the amount available to your body. Furthermore, it also prevents nutrients from being fully utilized in the body by altering their transport, storage, and excretion.

3. Long-Term Intake of Antacidsbuy vitamin b12 injections online

If you have gastrointestinal disorders like heartburn, peptic ulcer, or acid reflux, you may be prescribed antacids. Antacids neutralize the effect of stomach acids. Nonetheless, your body needs gastric acid to activate certain enzyme reactions to absorb vitamin B12. What this means, is that using antacids on a long-term basis can result in malabsorption of vitamin B12.

4. Weight Loss Surgery

Gastric or bariatric surgeries for weight loss can cause a vitamin B12 deficiency. This is because vitamin B12 is absorbed by first combining it with a protein called intrinsic factor produced in the stomach, then the B12 has to travel down the small intestine to an area called ileum for it to be absorbed properly. Due to changes in anatomy after these surgeries, this process can be negatively affected.

5. Atrophic or Autoimmune Gastritis

Gastritis is the inflammation or erosion of the stomach lining and it can be of 2 types – atrophic or autoimmune. Both conditions destroy the cells of the stomach lining and reduce the production of hydrochloric acid, thereby affecting the absorption of vitamin B12 from food. You might have to take B12 supplements to mitigate the deficiency since the gastritis diet may exclude meat and milk products, except yogurt.

6. Pernicious Anemia

Pernicious anemia is an autoimmune disease that affects the gastric mucosa and results in gastric atrophy. This leads to the destruction of parietal cells, achlorhydria, and failure to produce intrinsic factor, resulting in vitamin B12 malabsorption. Untreated pernicious anemia can cause vitamin B12 deficiency leading to megaloblastic anemia and neurological disorders, even in the presence of adequate dietary intake of vitamin B12.

7. Malabsorption of Vitamin B12 In The Small Intestine

Many stomach and intestinal diseases can affect cobalamin (or vitamin B12) absorption in the small intestine. Some of them are as follows:

  • Small intestine bacterial overgrowth (SIBO): The harmful bacteria use the available B12 before it has been absorbed by the small intestine, thereby leading to a deficiency.
  • Crohn’s disease: This condition is characterized by damaged ileum – a section of the small intestine responsible for vitamin B12 absorption.
  • Tapeworm infection: Tapeworms in your stomach feed off the vitamin B12 before it has been absorbed by the intestine. To avoid a B12 deficiency due to tapeworms, make sure you avoid eating undercooked meat or fish.

8. Breastfeeding by a Vitamin B12 Deficient Mother

Vitamin B12 deficiency is very common in infants born to vegan or vegetarian mothers, due to their lack of B12-rich foods. A study has shown that the prevalence of the deficiency among these infants is about 45%. Both unborn and newborn babies have a special need for vitamin B12 and if the mother is a vegetarian or a vegan, this need may not be met either through her diet for the unborn or through her breast milk for the newborn. As a consequence, vitamin B12 deficiency may develop in a breastfed infant within 3–6 months of age, severely affecting the baby’s growth.

9. Age above 50 Years

Studies have shown that the chances of vitamin B12 deficiency increase with age. An estimated 10–15% of people above 60 are believed to have this deficiency.  With age, the decrease in stomach acid secretion and the quantity of the digestive enzyme pepsin results in diminished absorption of vitamin B12. Older people with gastrointestinal problems are more susceptible to B12 deficiency, due to increased issues with absorption.

People over 50 years of age may show neurological changes due to vitamin B12 deficiency, resulting in an increased incidence of nervous and mental disorders among the elderly. In addition to this, vitamin B12 deficiency in the elderly has been associated with many health problems like elevated blood levels of homocysteine that could increase their chances of developing heart disease, stroke, and Alzheimer’s disease.

10. Genetic Factors

Some people can vitamin B12 absorption issues due to a hereditary gene mutation. The mutated genes can not only inhibit B12 absorption but also lead to abnormalities in the blood and brain.


Signs and Symptoms of Vitamin B12 Deficiency

Vitamin B12 deficiency is characterized by megaloblastic anemia, fatigue, weakness, constipation, loss of appetite, and weight loss. Neurological symptoms, such as numbness and tingling in the hands and feet, can also occur.

Additional indicators of vitamin B12 deficiency can include difficulty maintaining balance, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue. The neurological symptoms of vitamin B12 deficiency can occur without anemia, so early diagnosis and intervention are vital to avoid irreversible damage.

During infancy, signs of a vitamin B12 deficiency include failure to thrive, movement disorders, developmental delays, and megaloblastic anemia. However many of these symptoms are general and can result from a variety of medical conditions other than vitamin B12 deficiency.


Treatment: B12 Injections vs. Oral Supplements 

Early diagnosis and adequate treatment are critical to preventing damage due to vitamin B12 deficiency. Nearly two-fifths of the US population has a marginal amount of vitamin B12 (cobalamin) in their bodies, consequently putting them at a high risk of a deficiency.  You may think that the quick fix to a vitamin B12 deficiency is to eat foods that are rich in B12 or to take supplements, but the solution may not be that simple, as even meat eaters can be deficient in B12. Even with adequate dietary intake of vitamin B12, poor absorption in the gut can still lead to vitamin B12 deficiency.

Taking vitamin B12 as an oral supplement is largely a waste of money.  Most of what you swallow is just passed through your body, due to the fact that up to 99% will not be absorbed. Proper absorption of vitamin B12 requires normal function of the digestive system, specifically the stomach, pancreas, and small intestine.

Generally, it is more productive to consider injections. Taking vitamin B12 injections completely bypasses any digestive absorption issues and consequently get the vitamins to where they are needed.

Those with any condition listed above, or those who would simply like additional cobalamin, should buy vitamin B12 injections due to this method bypassing potential barriers to absorption and goes right into the bloodstream.  


Benefits of Vitamin B12 Injections

1. Remedy for Depression

One of the main reasons so many people continue to experience this condition is due to a large percentage of people suffering from vitamin B12, B6, and folate deficiencies. Vitamin B12 methylcobalamin injections and other B vitamins play a role in producing neurotransmitters that affect mood, DNA synthesis, as well as other neurological functions. Also, its deficiency can result in high levels of homocysteine in the blood which may have direct effects on the neurotransmitters implicated in depression.

Replacing these vitamins and maintaining a healthy diet of folic acid and vitamin b12 often help return the homocysteine level to normal, downgrade cortisol levels to prevent shrinkage of the major parts of the brain, and even treat depression. In addition, vitamin B12 methylcobalamin injections raise the available amount of SAMe (S-adenosylmethionine), an important compound which lifts the mood and works as a tricyclic antidepressant. If you are looking to buy vitamin b12 injections online, The HCG Institute is the perfect telemedicine choice that offers the bioactive form of vitamin b12.

2. Boosts Metabolism 

You may be wondering how vitamin B12 injections work to help you lose weight. While there is no solid evidence supporting the association between B12 and weight loss when you include vitamin B12 injections in your weight-loss programs you can have more energy. Additionally, methylcobalamin injections also boost your metabolism by converting carbohydrates into glucose for fuel, thus helping you shed unwanted pounds. A metabolism that works faster will inevitably allow you to burn calories faster. Buy vitamin B12 injections if you are looking to adopt a healthier lifestyle or drop some pounds! 

3. Plays an Important Role in the Prevention of Pernicious Anemia

With pernicious anemia, large, immature, nucleated cells circulate in the blood, however, they do not function as blood cells. This is a condition caused by too little vitamin B12 in the body due to the lack of intrinsic factor (IF) produced by the stomach lining. Without enough vitamin B12, red blood cells may have trouble getting out of the bone marrow because they will not divide normally and are too large to move into the bloodstream. Not having enough functioning red blood cells to carry oxygen through the body will leave you feeling tired and weak as a result. In order for the body to make red blood cells, it needs vitamin B12.

Vitamin B12 methylcobalamin injections aid in the formation of DNA and red blood cells that carry oxygen throughout the body by bypassing any digestive absorption process. If you are looking to buy a natural form of vitamin B12 injections online, contact The HCG Institute now to help you replenish your body’s supply of this vitamin. 

4. Helps Maintain Eye Health

Research shows that taking vitamin B12 with other B vitamins, including folic acid and vitamin B6, might help prevent an eye disease called age-related macular degeneration. A lack of B12 may leave the optic nerve more susceptible to damage. Furthermore, vitamin B12 injections were shown to benefit eye health by providing protection to the lens, which assists in the prevention of cataracts.

5. For Heart Health and Homocysteine Reduction 

Another important benefit of vitamin B12 methylcobalamin injection is its ability to lower the risk of atherosclerosis. Your homocysteine levels can become elevated due to a significant deficiency in vitamin B12. As a result, damage to the lining of the arteries can occur. In addition, high levels of homocysteine may also make the blood clot more easily than it should. This can increase the risk of blood vessel blockages. Vitamin B12 methylcobalamin converts homocysteine into methionine, which brings down homocysteine levels. The lower your homocysteine levels, the lower your risk for heart disease.

6. Optimizes the Health of the Nervous System

Finally, deficiency in B12 damages the myelin sheath that surrounds and protect nerves. This damage can cause the nerve signal transmission between the spinal cord and different parts of the body to be disrupted, and consequently, neurological problems such as peripheral neuropathy occur. If not treated, this condition may become permanently debilitating. 

Vitamin B12 methylcobalamin is vital for the proper functioning and development of the brain and nerve cells. It plays a significant role in the synthesis and maintenance of myelin sheaths that cover and protect the nerves of the central and peripheral nervous system, ensuring fast and effective nerve-impulse transmission.


Buy Vitamin B12 Injections Online

Considering all of the benefits outlined here, you may decide that a regimen of vitamin B12 methylcobalamin injections might be just what you need. For example, if you are seeking a way to boost your energy levels in a way that allows you to enjoy life more, then this could be it. Similarly, if you have a vitamin B12 deficiency due to a medical issue, we can assist you with that, too. In short, we’ve got you covered!

Vitamin B12 injections have exploded in popularity recently. If you are looking for genuine and authentic vitamin b12 supplements near you, then look no further! The HCG Institute has a variety of vitamin B12 injections from our licensed physicians to recommend for optimal functioning. In addition, our pharmacies conduct extensive quality testing on all products to confirm superior quality and efficacy.

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Vitamin B12 Methylcobalamin Products: 

1. Methylcobalamin Injections Each 1 ml contains 1000 mcg of methylcobalamin.

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2. Methyl Max Injections Each 1 ml contains 5000 mcg of methylcobalamin.

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3. Ultra Methyl Max Injection Each 1 ml contains 10,000 mcg of methylcobalamin.

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At The HCG Institute, our Methylcobalamin B12 injections offer the pure and biologically-preferred version of vitamin B12 to ensure you are getting all the nutrition your body needs to be healthy. We also make sure that you are getting the highest quality by sourcing our products at partner 503B FDA registered pharmacies in the United States. Most importantly, these pharmacies have extensive regulatory testing to ensure purity and consistency.

The HCG Institute serves patients nationwide through our telemedicine practice. Our board-certified physicians provide medical supervision and a prescription, and our Patient Care Coordinators are also here to help you on your journey to better health. In other words, we offer amazing support in the comfort, privacy, and convenience of your own home.

Get your prescription and order refills now. Buy vitamin b12 injections online safely, quickly, and confidentially by signing up in the Patient Portal or contact us at 877.228.2158 to discuss how our products can help restore your health and vitality.  Get started now!



  1. Herrmann W, Obeid R. Cobalamin deficiency. Subcell Biochem. 2012;56:301-22. doi: 10.1007/978-94-007-2199-9_16. Review. PubMed PMID: 22116706.
  2. Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr. 2015 Jan;69(1):1-2. doi: 10.1038/ejcn.2014.165. Epub 2014 Aug 13. PubMed PMID: 25117994.
  3. Riaz, Muhammad; Fouzia Iqbal; Muhammad Akram (2007). “Microbial production of vitamin B12 by methanol utilizing strain of Pseudomonas species”. Pak J. Biochem. Mol. Biol. 1. 40: 5–10.
  4. Watanabe F, Yabuta Y, Tanioka Y, Bito T. Biologically active vitamin B12 compounds in foods for preventing deficiency among vegetarians and elderly subjects. J Agric Food Chem. 2013 Jul 17;61(28):6769-75. doi: 10.1021/jf401545z. Epub 2013 Jul 2. Review. PubMed PMID: 23782218.
  5. “Vitamin B12. Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. 4 June 2015. Retrieved 5 April2019.
  6. Spence JD. Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke. Nutr Res. 2016 Feb;36(2):109-16. doi: 10.1016/j.nutres.2015.10.003. Epub 2015 Oct 21. Review. PubMed PMID: 26597770.
  7. Carmel R. How I treat cobalamin (vitamin B12) deficiency. Blood.2008;112:2214-21. [PubMed abstract]