Inositol Benefits for Weight Loss

When it comes to weight loss, not all vitamins and minerals are created equal. There are very few supplements that actually work or that have scientific evidence proving their efficacy. Because they are limited, certain supplements tend to stand out above the rest.

Myoinositol is one of these supplements and it works because it impacts hormones and acts as a secondary messenger in your cells. Not only does it help with weight loss but Myoinositol can also be used to treat health problems.  

In this article, we share information about what Inositol is, how it can promote weight loss, and how it can benefit your health. 


What is Inositol?

Inositol, or more precisely myo-inositol, is a carbocyclic sugar that is found in many plants and animals. It is also produced in the human body from the carbohydrates you eat. 

Although unofficially classified with the B vitamins because of similarities in biological function, Inositol is in fact cannot be defined as true vitamins. It is referred to as a vitamin-like substance or pseudovitamins instead due to its powerful effects on brain tissue, stress, and mood. 1


How Inositol Helps with Weight Loss?

Due to its many roles in the body, Inositol may have numerous health effects, including weight loss.  When paired with a healthy diet, Inositol may help accelerate the weight loss and fat mass reduction with a slight increase of percent lean mass. 

So how does Inositol work? Inositol is a compound related to B vitamins that help improve insulin sensitivity. Insulin sensitivity refers to how responsive your cells are to insulin. More specifically, the relationship between how much insulin needs to be produced in order to deposit a certain amount of glucose in the bloodstream. 2

Insulin determines how the body stores glucose and fat. It helps control blood glucose levels by signaling liver, muscle, and fat cells to take in glucose as fuel from the blood.


Some hormones including insulin also influence our appetite, metabolism , fat burning and body fat distribution. Inositol also helps orchestrate the activity of these hormones. 3 When one or more of your hormones becomes unbalanced, it can affect how your body reacts to glucose and insulin, increasing your risk of developing insulin resistance.

In people with insulin resistance, the cells are unable to use insulin effectively. When the cells cannot absorb glucose, levels of this sugar build up in the blood which will eventually lead to diabetes and obesity. 4


Other Health Benefits of Inositol in the Body

Inositol plays so many roles. All cells need myo-inositol to survive. Once they take it in, they transform it to phosphatidylinositol, a crucial component of cell membranes. Inositol has been studied in basic research and its potential has been recognized as very promising especially in treating a variety of health conditions in clinical trials.

  • Helps prevent diabetes

Inositol is shown to possess insulin-mimetic properties that help with type 2 diabetes and metabolic syndrome by supporting your body’s normal insulin processing mechanisms and in lowering post-prandial blood glucose. 

According to one study in C57BL/6 male mouse fed a high-fat diet (HFD), Inositol was efficient to improve insulin sensitivity and reduce fat accretion

Also, Inositol has been studied as a therapeutic option for the treatment of gestational diabetes. The main effect of inositol, when used in pregnancy, is decreasing the level of insulin resistance. 

  • Increases fertility and reduces PCOS symptoms in women

Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age. The ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs. The prevalence of infertility in people with PCOS is thought to be between 70 and 80 percent. 5

Myo-inositol is also used by the ovaries to make hormones that affect fertility and ovulation such as the follicle-stimulating hormone. A recent review suggests that inositol therapy can reduce insulin resistance, improve ovarian function, and reduce androgen levels in women with PCOS. 6

  • Protects the brain and nerves

Inositol, a newly identified non-nitrogenous molecule is present in large amounts in brain tissue that is involved in neuronal signaling and osmoregulation. Results suggest that the inositol lipid signalling pathways may generate both intracellular and extracellular signals in the brain involved in memory enhancement. 

Furthermore, cellular adaptation to osmotic stress is a vital process that protects cells from the effects of dehydration or edema. To maintain homeostasis cells produce osmolytes molecules designed to create osmolality in the brain. Myo-Inositol is one of the major osmolytes present in the CNS. 7


  • May improve mood and anxiety disorders

Researchers have found that some people with depression, anxiety, and compulsive disorders have lower levels of inositol in their brain. Taking Inositol may help balance important chemicals in your brain  are very important regarding anxiety and depression, such as serotonin and dopamine 8


Sources of Inositol

  1. Fresh fruits such as Citrus Fruits and Cantaloupe
  2. Vegetables
  3. Meat products
  4. Eggs
  5. Whole Grain Bread
  6. Supplements


Contact us Today and Experience the Benefits of Inositol! 

Are you having a hard time losing weight because of hormonal imbalance? Are you experiencing high blood glucose level due to insulin resistance? If you are one of them, Inositol supplement might be the answer to your problem. Contact The HCG Institute at 877.228.2158 and talk to our patient care coordinators on how to start supplementing your diet with Inositol for weight loss. 



  1. Balla T. Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev. 2013;93(3):1019-1137. doi:10.1152/physrev.00028.2012
  2. Gerli S, Papaleo E, Ferrari A, Di Renzo GC. Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci. 2007 Sep-Oct;11(5):347-54. PMID: 18074942.
  3. Melo AS, Ferriani RA, Navarro PA. Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice. Clinics (Sao Paulo). 2015;70(11):765-769. doi:10.6061/clinics/2015(11)09
  4. (Kalra B, Kalra S, Sharma J. The inositols and polycystic ovary syndrome. Indian J Endocrinol Metab. 2016;20:720–4.)
  5. Dai G, Yu H, Kruse M, Traynor-Kaplan A, Hille B. Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3290-9. doi: 10.1073/pnas.1606348113. Epub 2016 May 23. PMID: 27217553; PMCID: PMC4988571.
  6. Levine J. Controlled trials of inositol in psychiatry. Eur Neuropsychopharmacol. 1997 May;7(2):147-55. doi: 10.1016/s0924-977x(97)00409-4. PMID: 9169302