Lysine For Cold Sores and Herpes



lysine for herpes

L-Lysine Injections For Cold Sores and Herpes

Did you know that L-lysine can also be used as a treatment for cold sores or herpes simplex virus? Yes, that’s right! Some studies suggest that regular intake of L-lysine supplements may help prevent outbreaks of cold sores and genital herpes.

Lysine is an essential amino acid that is used in the biosynthesis of proteins. It plays a necessary role in carnitine production which is a nutrient responsible for converting fatty acids to be burned for energy. It also helps the body absorb calcium and plays an important role in the formation of collagen, a substance important for bones and connective tissues including skin, tendons, ligaments, and muscles.¹

What Are Cold Sores?

Cold sores, sometimes called fever blisters, are groups of fluid-filled lesions that are reddish and a little painful. They’re usually on the oral commissures or inside the mouth. 

Cold Sores are usually caused by a virus called herpes simplex (HSV-1), but can also be caused by herpes simplex type 2. The transmission of herpes simplex virus can be from person to person through direct contact, for instance through kissing, oral sex, or shared objects. It spreads more quickly when an infected person is experiencing a flare-up and when there are moist secretions from the blisters.²

Even after the sores themselves dry up and go away, people who got infected with HSV then carry the virus with them for the rest of their lives. It can stay dormant in nerve cells in your skin until relapse is triggered by stress, fatigue, extreme heat and cold temperatures, immune dysfunction, or hormonal imbalances.³


There are two categories of the herpes simplex virus. 

  • HSV-1 primarily causes oral herpes or cold sores and fever blisters around the mouth and on the face.

  • HSV-2 primarily causes genital herpes.

HSV-1 is the most common virus that affects 50%-80% of the American population, although many never have any symptoms.

Some of the symptoms associated with this HSV-1 include:

  • Small fluid-filled blisters
  • itching
  • fever
  • swollen lymph nodes
  • headaches
  • tiredness
  • lack of appetite
  • Painful eroded gums
  • Sore throat
  • Muscle aches

What does L-lysine do for Cold Sores?

The herpes simplex virus usually enters the body through a break in the skin around or inside the mouth. Herpes simplex virus (HSV) encodes seven proteins required for viral DNA synthesis and that includes arginine. The herpes simplex virus is highly dependent on arginine for its replication and the progression of viral infections which cause cold sores/genital herpes.

The role of L-lysine injection for cold sores is to interfere with arginine being absorbed into your body. It competes with arginine for inclusion into viral replicative processes. When arginine becomes unavailable, herpes viruses in cells are unable to complete a single replication cycle and cell damage is evident in infected cells. 

Lysine for cold sores may slow or stop the HSV-1 replication process but it cannot cure the person of the virus. One review found that L-lysine supplementation is more effective at reducing recurrences or improving symptoms than it is at reducing the severity and duration of an outbreak when taken at the beginning of a herpes outbreak.

lysine for cold sores

Treatment for Cold Sores and Herpes: L-lysine Injections 

Lysine is one of the essential amino acids, which are those that the body cannot make and that people need to obtain from dietary sources for their body’s basic needs.

However, people looking to use lysine to help treat cold sores will probably need to take L-lysine injection supplements to boost their lysine intake. 

Our L-lysine Kit Contains

  • L-lysine vial (Pharmaceutical-grade)
  • syringes
  • alcohol prep pads
  • physician consultation 


What is the Lysine dosage for cold sores? 

L-lysine supplementation appears to be ineffective for the treatment of herpes simplex lesions with doses below 1 g/day without low-arginine diets. Doses above 3 g/day appear to improve patients’ subjective experience of the disease. 

Some sources also recommend that people with a history of herpes infections take 1,000 to 3,000 milligrams (mg) of lysine supplements a day. 


Lysine Treatment Prescribed by a Physician 

You should take dietary supplements under the supervision of a knowledgeable health care provider. L-lysine can have side effects and possible interactions with other medications. 

While lysine in the diet is considered safe, take cautions when taking large amounts of lysine because excessive doses may cause gallstones. There have also been reports of renal dysfunction, including Fanconi syndrome and renal failure. 

Talk to your doctor before taking supplemental L-lysine injections if you have kidney disease, liver disease, or if you are pregnant or breastfeeding.


Buy L-Lysine Online Near You! 

If you’re looking to supplement our body with L-lysine for cold sores, The HCG Institute is the best online store for you. Our products are ѕресіfісаllу formulated for human uѕе аnd thаt hаvе bееn рrоduсеd bу а rерutаblе U.S соmроundіng рhаrmасу. 

We are a telemedicine practice that helps a lot of people get a doctor’s prescription without the need to go to your local office. Оnсе thе dоctоr rеvіеwѕ уоur mеdіcаl іnfоrmаtіоn аnd ѕuррlіеѕ thе рhаrmасу wіth а рrеѕсrірtіоn, thе рhаrmасу wіll ѕhір thе l-lysine injections dіrесtlу tо уоu. It’s as easy as one, two, three! What are you waiting for? Contact us now



  1. National Center for Biotechnology Information. PubChem Database. Lysine, CID=5962, (accessed on May 17, 2020)
  2. [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Cold sores: Overview. 2018 Jul 12. Available from:
  3. Grinde B. Herpesviruses: latency and reactivation – viral strategies and host response. J Oral Microbiol. 2013;5:10.3402/jom.v5i0.22766. Published 2013 Oct 25. doi:10.3402/jom.v5i0.22766
  5. Sanchez MD, Ochoa AC, Foster TP. Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways. Antiviral Res. 2016 Aug;132:13-25. doi: 10.1016/j.antiviral.2016.05.009. Epub 2016 May 15. PubMed PMID: 27192555; PubMed Central PMCID: PMC4980161.
  6. National Center for Biotechnology Information. PubChem Database. Lysine, CID=5962, (accessed on May 17, 2020)
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