N-acetylcysteine injections N-Acetylcysteine (NAC) injections, are the N-acetylated form of the amino acid cysteine. When injected, they are rapidly deacetylated during first-pass metabolism.

Deacetylation is the removal of an acetyl group from a chemical compound to yield the essential amino acid cysteine. It is stored by the liver which uses and releases it as needed. 

NAC helps facilitate essential biological functions by bonding with two other amino acids—glutamine and glycine—to create glutathione, a powerful antioxidant that plays a key role in regulating numerous cellular activities and helps keep the immune system in check. 1  

When glutathione store is depleted due to limited cysteine, the deacetylation of NAC provides cysteine to accelerate glutathione (GSH) production to maintain its normal range. GSH is a cysteine-containing tripeptide that serves as a detoxifying agent, a coenzyme for multiple enzymes, and a key component of the electron transport system.

Increasing the amount of NAC in the body may boost levels of some neurotransmitters, and this may improve a person’s mental function.

Benefits of N-Acetylcysteine (NAC) Injections

  1. Accelerate Glutathione production or GSH which is the most important low molecular weight antioxidant synthesized in cells.
  2. NAC is an antioxidant that may reduce inflammation.
  3. N-Acetylcysteine (NAC) Injections were found to reduce the recurrence of preterm birth in patients with bacterial vaginosis.
  4. Preliminary studies in animals also demonstrate that NAC may help with heroin dependence and the adverse effects of alcohol consumption.2 
  5. Doctors can use N-Acetylcysteine (NAC) Injections to treat acetaminophen (Tylenol) poisoning by binding the poisonous forms of acetaminophen that are formed in the liver. Acetaminophen is an analgesic that can relieve aches, pains, and a fever. If a person experiences an overdose of this drug, administering NAC within 10 hours may help reduce the risk of associated liver damage. 3 
  6. NAC may improve insulin sensitivity and help reduce high blood sugar in people with PCOS. Futhermore, by increasing glucose tolerance, N-acetylcysteine may prevent people with prediabetes from progressing to diabetes. 4 
  7. For people with chronic lung conditions and excess mucus, such as bronchitis or chronic obstructive pulmonary disease (COPD), some doctors recommend NAC. A 2015 analysis published in European Respiratory Review concluded that 1,200 milligrams (mg) of N-acetylcysteine per day reduced the incidence and severity of exacerbations after evaluating 13 studies and a total of 4,155 people with COPD. 5 
  8. Most doctors would recommend NAC to supplement other treatments to help alleviate symptoms of various psychiatric conditions, including bipolar disorderobsessive-compulsive disorder, and schizophrenia
  9. N-acetylcysteine is often said to reduce the risk of heart disease by reducing the oxidative stress on the heart and cardiovascular system by reducing the levels of homocysteine in the blood. Homocysteine is an amino acid that is an independent risk factor for heart disease. 6
  10. N-acetylcysteine (NAC) has been used in clinical practice to treat critically ill septic patients, and more recently for COVID-19 patients. NAC has antioxidant, anti-inflammatory and immune-modulating characteristics that may prove beneficial in the treatment and prevention of SARS-Cov-2. Taking N-acetyl cysteine may seem to reduce flu symptoms. 7  

Side effects:

N-acetylcysteine (NAC) injections are considered safe and well-tolerated if used appropriately. But NAC supplementation may also cause side effects in some that are generally mild and typically resolve on their own once treatment is stopped. These may include:

  • diarrhea
  • eye irritation
  • fatigue
  • nausea
  • skin rash
  • vomiting

Risks

  1. You may be told to avoid NAC if you have bleeding problems such as hemophilia or Von Willebrand disease. N-acetylcysteine can slow blood clotting and should be avoided in people with bleeding disorders. You will likely be told to stop NAC two weeks before any elective surgery.
  2. You may be told to avoid NAC if you have asthma. Inhaling this drug may put you at increased risk of wheezing, tightness in your chest, and trouble breathing (bronchospasm).
  3. If you’re pregnant or breastfeeding, you must check with a doctor before using N-Acetylcysteine (NAC) injections.

Interactions

If you take any medicines regularly, talk to your doctor before you start using NAC injections. They could interact with nitroglycerin, including blood thinners and certain blood pressure medicines. it can cause nitroglycerine to work more intensely and cause an unsafe drop in blood pressure.

There is also a theoretical risk of hypoglycemia (low blood sugar) if N-acetylcysteine is taken with diabetes medications. The routine monitoring of blood glucose can help identify any abnormal drops in blood sugar.

 

Buy NAC Injections Online at The HCG Institute

NAC injection is available for purchase online at The HCG Institute. To ensure the utmost safety and quality, only buy NAC supplement injections that have been manufactured from pharmacies in the United States that comply with strict guidelines that pharmaceutical manufacturers follow. 

Anyone who wishes to try NAC supplements should speak with our knowledgeable patient care coordinators to fully understand the risks and benefits of N-acetylcysteine and whether you actually need the supplement or not.

 

References:

1. Schmitt B, Vicenzi M, Garrel C, Denis FM. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study. Redox Biol. 2015;6:198-205. doi:10.1016/j.redox.2015.07.012

2. Sansone RA, Sansone LA. Getting a Knack for NAC: N-Acetyl-Cysteine. Innov Clin Neurosci. 2011;8(1):10-14.

3. Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini A. A Review on Various Uses of N-Acetyl Cysteine. Cell J. 2017;19(1):11-17. doi:10.22074/cellj.2016.4872.

4. Coyle LC, Rodriguez A, Jeschke RE, Simon-Lee A, Abbott KC, Taylor AJ. Acetylcysteine In Diabetes (AID): a randomized study of acetylcysteine for the prevention of contrast nephropathy in diabetics. Am Heart J. 2006 May;151(5):1032.e9-12. doi: 10.1016/j.ahj.2006.02.002. PMID: 16644332.

5. Cazzola M, Calzetta L, Page C, Jardim J, Chuchalin AG, Rogliani P, Matera MG. Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis. Eur Respir Rev. 2015 Sep;24(137):451-61. doi: 10.1183/16000617.00002215. PMID: 26324807.

6. Wiklund O, Fager G, Andersson A, Lundstam U, Masson P, Hultberg B. N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels. Atherosclerosis. 1996 Jan 5;119(1):99-106. doi: 10.1016/0021-9150(95)05635-1. PMID: 8929261.

7. Shi Z, Puyo CA. N-Acetylcysteine to Combat COVID-19: An Evidence ReviewTher Clin Risk Manag. 2020;16:1047-1055. Published 2020 Nov 2. doi:10.2147/TCRM.S273700.