The Health Benefits of Folic Acid

Folic Acid is one of the B vitamins that play roles in many organs and bodily functions. It helps several enzymes doFolic Acid their jobs properly ranging from the body’s conversion of food into energy (metabolism), create new blood cells, transporting oxygen and energy-containing nutrients around the body, and maintain healthy skin cells, brain cells, and other body tissues. This article explains the health benefits of vitamin B9 folic acid and when administered together with vitamin B12 Hydroxocobalamin.


Understanding The Health Benefits of Folic Acid

Folic acid is the simple, man-made form of the B vitamin folate, the natural form of vitamin B9. 

Folic acid is used for preventing and treating low blood levels of folate (folate deficiency) and high blood levels of homocysteine, an amino acid that can exert harmful effects in the body if it is present in high amounts. 1 

Folic acid is critical during periods of rapid growth, such as during pregnancy and fetal development because cells must have folic acid for them to duplicate themselves. Folic acid makes up the base pairs found in every DNA molecule.

The U.S. Public Health Service recommended that women increase the intake of folates and take folic acid supplements every day before becoming pregnant and during pregnancy to prevent serious birth defects affecting the brain and spinal cord. 2 

Folic acid is also needed to produce healthy red blood cells which carry oxygen to all parts of your body. Without enough oxygen, your body can’t work as well as it should. 

Another health benefit of Folic acid is its use for many other conditions including depression, stroke, a decline in memory and thinking skills, and many others.


Good sources of folate

Folic acid with hydroxocobalamin B12

Folic acid is present in fortified foods and sold as a supplement. Supplement form is actually better absorbed than that from food sources—85% vs. 50%, respectively.

Since 1998, folic acid has been added to cold cereals, flour, bread, pasta, bakery items, cookies, and crackers, as required by federal law to help reduce the risk of neural tube defects. 3

Other good sources are: 

  • dark green leafy vegetables 
  • beef liver
  • avocado
  • papaya
  • citrus fruits
  • eggs
  • beans

Symptoms of folate deficiency

The addition of folic acid to grain products has made folate deficiency uncommon. However, the following conditions may put people at increased risk:

  • Alcoholism. Alcohol interferes with the absorption of folate. It speeds the rate that folate breaks down and is excreted from the body. 4 
  • Pregnancy. The need for folate increases during pregnancy as it plays a role in fetal cell development.
  • Intestinal surgeries or digestive disorders. Celiac disease, inflammatory bowel disease, and surgeries involving the digestive organs may also decrease the absorption of folate.
  • Genetic variants. People carrying a variant of the gene MTHFR cannot convert folate to its active form to be used by the body.

Possible signs and symptoms of a folate deficiency may include:

  • megaloblastic anemia (a condition arising from a lack of folate in the diet or poor absorption that produces fewer red blood cells, and larger in size than normal); 
  • fatigue
  • headache
  • heart palpitations
  • irritability
  • sores on the tongue or in the mouth
  • skin or nail changes
  • shortness of breath
  • difficulty concentrating
  • hair loss
  • pale skin
  • mouth sores.

Recommended Intake:

The Recommended Dietary Allowance for folate is listed as micrograms (mcg) of dietary folate equivalents (DFE). 

  • Men and women ages 19 years and older should aim for 400 mcg DFE. 
  • Pregnant and lactating women require 600 mcg DFE and 500 mcg DFE, respectively. 
  • People who regularly drink alcohol should aim for at least 600 mcg DFE of folate daily since alcohol can impair its absorption.

It is extremely rare to reach a toxic level when eating folate from food sources. B vitamins such as folic acid and hydroxocobalamin B12 are water-soluble, which means they are transported through the body by fluids and any excess amounts are excreted along with those fluids. The body doesn’t store these vitamins, so they must be replenished daily.5 

However, an upper limit for folic acid from fortified food or supplements (not including folate from food) is set at 1,000 mcg daily 

Taking more than this can mask symptoms of vitamin B-12 which can cause permanent nerve damage.6 

Benefits of taking Folic Acid with Hydroxocobalamin B12

Although Folic acid carries out its unique function, it can also produce great effects on the body when used in combination with other B vitamins especially, vitamin B12.

Folic acid works in conjunction with Hydroxocobalamin B12 to help the body digest and use proteins. Administering folic acid with hydroxocobalamin injection will ensure that protein is metabolized properly, which will help your body maintain a stable insulin level. Keeping a steady level of insulin can immediately help your body burn the fat it gets from the foods you eat instead of storing it. Burning fat increases weight loss.

Folic acid works closely with vitamin B12 in making red blood cells and helps iron function properly in the body. This combination breaks down homocysteine to create other chemicals your body needs. High levels of homocysteine are associated with dementia, heart disease, and stroke. 7 

Having normal vitamin B12 and serum folate status is associated with a reduced prevalence of anemia and a significantly reduced prevalence of cognitive impairment. 

All B vitamins including folic acid and hydroxocobalamin help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These are also needed for healthy skin, hair, eyes, liver, and for the nervous system to function properly.

The absorption rate:

When Folic acid with hydroxocobalamin B12 is injected directly into the bloodstream they bypass the digestive system and are pushed directly into cells where they can be more effectively utilized by the body.8

Enjoy the health benefits of Folic acid with hydroxocobalamin from The HCG Institute by giving few shots weekly is an effective way to increase your energy, strengthen your immune system, and promote weight loss. 


1. Green R, Datta Mitra A. Megaloblastic Anemias: Nutritional and Other CausesMed Clin North Am. 2017 Mar;101(2):297-317.

2. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm Rep. 1992;41(RR-14):1–7.

3. Williams J, Mai CT, Mulinare J, et al. Updated estimates of neural tube defects prevented by mandatory folic acid fortification – United States, 1995–2011. MMWR Morb Mortal Wkly Rep. 2015;64(1):1–5.

4.Halsted CH, Villanueva JA, Devlin AM, Chandler CJ. Metabolic interactions of alcohol and folate. J Nutr. 2002 Aug;132(8 Suppl):2367S-2372S. doi: 10.1093/jn/132.8.2367S. PMID: 12163694.

5. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients. 2016;8(2):68. Published 2016 Jan 27. doi:10.3390/nu8020068


7. Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, Paroni R, Magni F, Sandoli EP, Lucotti P, Costa S, Fermo I, Galli-Kienle M, Origgi A, Margonato A, Piatti P. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol. 2004 Oct