Methylcobalamin Injections

Methylcobalamin is a specific form of water-soluble vitamin B12 that is not naturally produced by the body in sufficient quantities and must be obtained through diet, supplementation, or prescription formulations. This vitamin is essential for overall neurological health and energy production. Compounded Methylcobalamin injections are prepared outside the FDA approval process and are not reviewed by the FDA for safety, effectiveness, or quality.

Compounded methylcobalamin injections may be prescribed by a licensed healthcare provider for patients with clinically appropriate vitamin B12 deficiency or when injectable vitamin B12 supplementation is considered medically appropriate. The decision to prescribe this compounded medication is based on an individualized medical evaluation.

Potential Benefits

– May support normal red blood cell formation
– May support normal nerve function
– May support normal energy metabolism
– May play a role in normal cardiovascular function
– May support normal neurological function

These statements reflect the role of B12 as an essential nutrient as documented in the
scientific literature. They do not constitute claims that this compounded product diagnoses, treats, cures, or prevents any disease or condition. Individual results vary significantly and are not guaranteed.

Product Purchase Includes:

– Medication
– Provider consultation
– Syringes
– Alcohol Pads
– Program guide
– Administration video

Administration and Frequency

– Available in Subcutaneous (SQ) and Intramuscular (IM) Injections
– Three times weekly
– As directed by your prescribing provider

Contraindications

Compounded Methylcobalamin injections should not be used in individuals who:
– Have a known hypersensitivity or allergy to cyanocobalamin, methylcobalamin, cobalt, or any component of the formulation
– Have Leber's disease (hereditary optic nerve atrophy); B12 administration may cause rapid optic atrophy in these patients
– Have polycythemia vera; B12 may accelerate red blood cell production in ways that may be harmful in this condition

Use during pregnancy or breastfeeding should occur only if a licensed healthcare provider determines that potential benefits outweigh potential risks.

Warnings and Precautions

– Hypokalemia: B12 therapy may cause a drop in potassium levels (hypokalemia), particularly during early treatment in patients with significant B12 deficiency. Patients should be monitored by their prescribing clinician, especially those taking cardiac medications.

– Masking of folic acid deficiency: B12 supplementation may correct hematological abnormalities associated with folic acid deficiency while leaving neurological damage unaddressed. Folic acid status should be evaluated before starting B12 therapy.

– Acneiform eruptions: Skin reactions including acneiform eruptions have been reported in some patients receiving injectable B12.

– Anaphylaxis: Rare cases of anaphylaxis have been reported following injection. Patients with a history of sensitivity to cobalamin should discuss this with their provider before starting.

Patients should inform their healthcare provider of all medical conditions, medications, and supplements prior to receiving this compounded formulation.

Potential Side Effects

Reported side effects may include:
– Injection site pain, redness, or irritation
– Mild diarrhea
– Itching or rash
– Headache
– Dizziness
– Nausea
– Hypokalemia (low potassium); see Warnings above
– Acneiform skin eruptions

Serious adverse reactions are uncommon but may occur. Seek immediate medical attention for signs of a severe allergic reaction including hives, swelling of the face, lips, tongue, or throat, difficulty breathing, or chest tightness. Contact your prescribing provider promptly if you experience unexpected or concerning symptoms.